Synthesis, Characterization and antimicrobial activity of transition metal (II) complexes of schiff bases derived from 2-aminophenol and vanillin.
Publication Date : 01/03/2016
Some new transition metal complexes of Co(II), Ni(II), Cu(II) and Zn(II) with Schiff base ligand derived from condensation of 2-amino phenol with vanillin. Both the ligands/complexes were characterized on the basis of elemental analysis, 1H- and 13C-NMR, IR and UV-visible spectral data. The invitro antibacterial and antifungal activities of the complexes were tested using number of bacteria species such as E. coli, Staphylococcus aureus and fungal species such as Aspergillus nidulence and candida albicans. The complexes were formed in moderate yields and they are of various colours and have sharp melting points. The purity and composition of the schiff bases and the metal(II) complexes were established by elemental analysis which suggests a metal : ligand ratio of 1:2. The IR spectra revealed that the complexes coordinated through azomethine nitrogen and methoxy oxygen of the ligands. Further conclusive evidence of the coordination of the schiff bases with the metal ions was shown by the appearance of new bands due to ѵ(M-N) and ѵ(M-O) in the metal complexes. Based on the electronic spectral transitions, an octahedral structure has been assigned to all the complexes except Zn(II) complexes which has been assigned tetrahedral structure. Measured molar conductance showed that the complexes are non electrolytes and are soluble in protic solvents like methanol and ethanol. Some complexes showed good antibacterial activities against the tested bacteria, therefore the possible use of the complexes as antibiotic can be suggested. Keywords: Synthesis, characterization, antimicrobial studies, schiff base vanillin, 2-aminophenol.
No. of Downloads :